Department of Oral Biology
The State University of New York at Buffalo
3435 Main Street
Buffalo, NY 14214
E-mail: [email protected]
2008 Ph. D. China Agricultural University
2003 MS Shenyang Agricultural University
1993 Bachelor of Science Shenyang Agricultural University
2008 – Present Research Scientist, University at Buffalo, SUNY
Summary: Using genetic, biochemical, genomic, proteomic and animal model approaches to understand the basic biology and pathogenesis of the pathogenic spirochetes B. burgdorferi. Current research mainly focused on understanding the roles of motility and chemotaxis in the pathogenesis of Lyme disease; understanding the molecular mechanisms of motility and chemotaxis of the Lyme disease spirochete Borrelia burgdorferi.
2003 - 2008 Research Assistant, China Agricultural University, Beijing, China
Summary: Characterized genes involved in appressorium development of Magnaporthe grisea;
Decode the molecular basis of the diseases caused by fungal pathogen using comparative and global functional analysis.
1993 – 2003 Assistant (Associate) Research Fellow, Liaoning Academy of Agricultural Sciences, China
Summary: Using novel biotechnology to improve vegetable varieties resistance to disease; breeding, testing and extension of new vegetable varieties.
My primary interest focused on understanding the basic biology and pathogenesis of the pathogenic bacteria, including the Lyme disease spirochete Borrelia burgdorferi and the oral spirochete Treponma deticola, by using genetic, molecular, genomics and animal model approaches to identify genes essential for cell development and pathogenesis and regulation of virulence factors of pathogens. Current research goals are to understand the molecular mechanisms of motility and chemotaxis of the Lyme disease spirochete; to determine the role of motility and chemotaxis in the pathogenesis of Lyme disease; to determine the roles of bacterial two-component signaling pathways and protease in the biology and pathogenesis of the spirochetes, including Borrelia burgdorferi and Treponma deticola.
Peer reviewed papers:
Gordon Research Conference: Biology of Spirochetes. January 2010. Ventura,
California. “FlgJ homology in Borrelia burgdorferi affects flagellar hook orientation and number of periplasmic flagella” Kai Zhang (Poster presenter), Jun Liu, and Chunhao Li.
BLAST XII (Bacterial locomotion and signal transduction). January, 2013. Tucson, AZ. "3-D visualization of bacterial flagellar assembly in Borrelia burgdorferi." Xiaowei Zhao, Kai Zhang, Tristan Boquoi, Bo Hu, Chris Li, Md A. Motaleb, Kelly A. Miller, Nyles W. Charon, Steven J. Norris, and Jun Liu.
Proceedings of the Annual Meeting of Chinese Society for Plant Pathology (2007). August, 2007. Yangling, Shaanxi. MgCON3 specifically affects conidia morphogenesis of rice blast fungus Magnaporthe oryzae.
Proceedings of the Annual Meeting of Chinese Society for Plant Pathology (2005). August, 2005. Nanyang, Henan. An HOMEO- domain protein control appressorum mature of rice blast fungus Magnaporthe oryzae.