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Kai Zhang, Ph. D.

Primary Affiliation
University at Buffalo
Status
Researcher
City
Buffalo
Country
United States of America

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Kai Zhang

Department of Oral Biology

The State University of New York at Buffalo

3435 Main Street

Buffalo, NY 14214

Phone: 716-342-5912

E-mail: [email protected]

 

EDUCATION

2008                Ph. D.                           China Agricultural University

 

2003                MS                               Shenyang Agricultural University

 

1993                Bachelor of Science    Shenyang Agricultural University

 

WORK EXPERIENCE

2008 – Present        Research Scientist, University at Buffalo, SUNY                   

Summary: Using genetic, biochemical, genomic, proteomic and animal model approaches to understand the basic biology and pathogenesis of the pathogenic spirochetes B. burgdorferi. Current research mainly focused on understanding the roles of motility and chemotaxis in the pathogenesis of Lyme disease; understanding the molecular mechanisms of motility and chemotaxis of the Lyme disease spirochete Borrelia burgdorferi.

2003 - 2008               Research Assistant, China Agricultural University, Beijing, China

Summary: Characterized genes involved in appressorium development of Magnaporthe grisea;

Decode the molecular basis of the diseases caused by fungal pathogen using comparative and global functional analysis.

1993 – 2003              Assistant (Associate) Research Fellow, Liaoning Academy of Agricultural Sciences, China

Summary: Using novel biotechnology to improve vegetable varieties resistance to disease; breeding, testing and extension of new vegetable varieties.


RESEARCH INTEREST

My primary interest focused on understanding the basic biology and pathogenesis of the pathogenic bacteria, including the Lyme disease spirochete Borrelia burgdorferi and the oral spirochete Treponma deticola, by using genetic, molecular, genomics and animal model approaches to identify genes essential for cell development and pathogenesis and regulation of virulence factors of pathogens. Current research goals are to understand the molecular mechanisms of motility and chemotaxis of the Lyme disease spirochete; to determine the role of motility and chemotaxis in the pathogenesis of Lyme disease; to determine the roles of bacterial two-component signaling pathways and protease in the biology and pathogenesis of the spirochetes, including Borrelia burgdorferi and Treponma deticola.

 

PUBLICATIONS

Peer reviewed papers:

  1. Jiagang Tu, Xiaowei Zhao, Akarsh Manne, Kathryn Lees, Aaron Yerke, Kai Zhang, Chunhao Li, Steven J. Norris, Md A. Motaleb, Jun Liu. 2014. Molecular architecture and mechanism of the flagellar export apparatus in Borrelia burgdorferi (Submitted)

 

  1. Kai Zhang, Hongbin Xu, Jun Liu, Nyles W. Charon, and Chunhao Li. 2014. A MCP-like protein (BB0569) is essential for chemotaxis of the Lyme disease spirochete Borrelia burgdorferi. (Submitted)

 

  1. Zhao X, Zhang K, Boquoi T, Hu B, Motaleb MA, Miller KA, James ME, Charon NW, Manson MD, Norris SJ, Li C, Liu J. 2013. Cryoelectron tomography reveals the sequential assembly of bacterial flagella in Borrelia burgdorferi. Proc. Natl. Acad. Sci. U. S. A. 110:14390–14395. (co-first author)
  2. Zhang K, Tong BA, Liu J, Li C. 2012. A single-domain FlgJ contributes to flagellar hook and filament formation in the Lyme disease spirochete Borrelia burgdorferi. J. Bacteriol. 194:866–874
  3. Zhang K, Liu J, Tu Y, Xu H, Charon NW, Li C. 2012. Two CheW coupling proteins are essential in a chemosensory pathway of Borrelia burgdorferi. Mol Microbiol. 85(4):782–794.
  4. Sze CW, Zhang K, Kariu T, Pal U, Li C. 2012. Borrelia burgdorferi needs chemotaxis to establish infection in mammals and to accomplish its enzootic cycle. Infect. Immun. 80:2485–2492.
  5. Kurniyati K, Zhang W, Zhang K, Li C. 2013. A surface-exposed neuraminidase affects complement resistance and virulence of the oral spirochaete Treponema denticola. Mol Microbiol. 89:842–856 10.1111/mmi.12311
  6. Li, C., H. Xu, K. Zhang, and F. T. Liang. 2010. Inactivation of a putative flagellar motor switch protein FliG1 prevents Borrelia burgdorferi from swimming in highly viscous media and blocks its infectivity. Mol. Microbiol. 75:1563-1576.

 

Conference abstracts:

Gordon Research Conference: Biology of Spirochetes. January 2010. Ventura,

California. “FlgJ homology in Borrelia burgdorferi affects flagellar hook orientation and number of periplasmic flagella” Kai Zhang (Poster presenter), Jun Liu, and Chunhao Li.

 

BLAST XII (Bacterial locomotion and signal transduction). January, 2013. Tucson, AZ. "3-D visualization of bacterial flagellar assembly in Borrelia burgdorferi." Xiaowei Zhao, Kai Zhang, Tristan Boquoi, Bo Hu, Chris Li, Md A. Motaleb, Kelly A. Miller, Nyles W. Charon, Steven J. Norris, and Jun Liu.

 

Proceedings of the Annual Meeting of Chinese Society for Plant Pathology (2007). August, 2007. Yangling, Shaanxi. MgCON3 specifically affects conidia morphogenesis of rice blast fungus Magnaporthe oryzae.

 

Proceedings of the Annual Meeting of Chinese Society for Plant Pathology (2005). August, 2005. Nanyang, Henan. An HOMEO- domain protein control appressorum mature of rice blast fungus Magnaporthe oryzae.

 

PATENTS

  1. Youliang Peng, Kai Zhang, Wensheng Zhao, Yujun Zhang, Tao Shi, MgPTH12 controls appressorium mature and pathogenesis of Magnaporthe grease and its application. China Patent ZL200510109444.X 2005
  2. Youliang Peng, Jingyu Liu, Wensheng Zhao, Yujun Zhang, Kai Zhang, Tao Shi, A novel gene MgCON3 controls conidia formation of Magnaporthe grease  and its application. China Patent ZL200610103664.6 2006
      • Normal 6637197cfb5e4ebc9bbbeae1da11f481
        Journal
        The International Journal of Microbiology and Parasitology is a peer-reviewed, open access journal that publishes original research articles, review articles, essays, and historical perspectives. The IJMP scope includes bacteriology, fungi, microbiology, parasites, prions and prion diseases, protozoa, protozoology, virus research, and related subjects.