Mohamed El-Saeed Abdel-Hai
El-Mansoura, Egypt Date of Birth: 4th July, 1971
Tel: 002 050 2343964 , 002 011 28235810, 002 01028537563 , 002 01003161644
E-mail: [email protected] Skype: mohamad.ghanim5
Prof. Dr. Hartmut Seliger, Ulm University, Germany. E-mail: [email protected]
Prof. Dr. Winfried H. Albert, Laim 21- 5340 St. Gilgen – Austria. E-mail: [email protected]
1993 B.Sc. of Chemistry, Faculty of Science, Mansoura University.
A brief summary of the PhD's thesis
Liver biopsy is invasive, requires an experienced gastroenterologist, examination is required by a professional histopathologist, adds expense, and is associated with complications and mortality patients with chronic hepatitis C. There is a clinical need for noninvasive measurement of liver fibrosis both to diagnose significant liver fibrosis and to monitor the effects of therapy on fibrogenesis and fibrolysis. Selected serum samples from 118 liver fibrosis patients associated with chronic HCV infection 60 males and 58 females (aged 21 to 73 years, mean age 46.1±10.44) and 50 age matched healthy volunteers (27 males and 23 females) were included in the present study from Internal Medicine Dept., Mansoura University Hospitals, Mansoura, Egypt. The HCV infection was diagnosed based on biochemical, serologic and histological criteria. All samples of 118 fibrotic liver patients showing positive result for anti-HCV antibodies using ELISA as confirmatory test. Collagen III was identified in serum samples of patients with HCV induced liver fibrosis at 70 kDa using collagen III polyclonal antibody and western blot analysis technique. The purified antigen gives a single sharp band at 70 kDa when it was resolved by SDS–PAGE and stained with coomassie blue. The 70 kDa purified collagen III showed high reactivity towards collagen III polyclonal antibody. The serum levels of hyaluronic acid were determined by radioimmunoassay. Plotted receiver-operating characteristic (ROC) curves, was used to assess and compare the diagnostic accuracy of biomarkers. Collagen III in combination with hyaluronic acidcan identify 89.8 % of liver fibrosis patients. However, the detection rate of collagen III in combination with hyaluronic acidin healthy volunteer was 6%. In conclusion, we have developed noninvasive diagnosis that can be applied to patients who either have contraindications or refuse liver biopsy for the management of their HCV infection.
A brief summary of the Master's thesis
This work had been done in an attempt to prepare inorganic ion exchangers that can be of help in various areas of nuclear fuel cycle. To satisfy these purposes, titanium molybdate was prepared. Titanium molybdate which is among several new synthetic ion exchange materials, double salts of polybasic acids with tetravalent metal types is very promising. Characterization of this material using x-ray diffraction, x-ray florescence, thermal analysis and infrared spectrometry was conducted. The sorption behavior of uranium and sodium ions on titanium molybdate was conducted. Also, the retention behavior of uranium using polyurethane foams was achieved. Chromatographic behavior of uranium on a column packed with crown ether-loaded foams was achieved. The sorption efficiency and the recovery of uranium (VI) from the aqueous solution by the loaded foam columns were found in the range 40%. The values of (HETP), the number of theoretical plates (N), the breakthrough capacity and the critical capacity were found in the range 0.12 ± 0.01mm, 64, 58.3 mg/g and 41.66 mg/g, respectively. The sepctrophotometric determination of uranium after pre-concentration on the crown ether loaded foam columns followed by elution with acetone was achieved successfully employing arsenazo(III).
The use of nanoparticles to diagnose and treat diseases. Radiopharmaceuticals and the applications of radioactive isotopes and its use to diagnose diseases. Synthesis and characterization of inorganic ion exchanger and its use to treat radioactive wastes and water decontamination by polyurethane foam loaded by chelating agents. Separation of radioactive isotopes from aqueous solutions. Using of biochemical markers in biological fluids to diagnose diseases using spectrophotometry and radiometry. Drug design based computer.
· 2013 Head of Basic Sciences Department, Buraydah Colleges, Buraydah, KSA.
· 2012 Head of Pharmaceutical Chemistry Department, Buraydah colleges, Buraydah, KSA.
· 2010 – Up to date Assistant professor of clinical biochemistry, Faculty of Pharmacy, Buraydah colleges, Buraydah, KSA.
· 1998–2010 Lecturer of Radio-analytical Chemistry and clinical biochemistry, Atomic Energy Authority, Cairo, Egypt.
(On leave to work in KSA since 2010).
· 2004–2009 Medical laboratory specialist and medical manager of Ablan medical laboratory, Ablan polyclinic, Hafr El-Batin, KSA.
· 1995-2004 Medical laboratory specialist and medical manager for Alwafaa medical lab, Egypt.
· 1994-2004 Medical laboratory specialist in El-Tawfikia hospital, Egypt,
· 1994-2004 Medical laboratory specialist in Cairo lab, Egypt, (part time).
· 1994-1998 Medical representative in Bohringer Manhiem (Germany) (Roche diagnostics), Egypt.
· Licensed as medical laboratory specialist, Egyptian ministry of health, Egypt.
· 2004-Up to date Licensed as medical laboratory specialist (Clinical Biochemistry), Saudi commission for health specialties, KSA.
· Membership of syndicate of scientific professionals, Egypt.
· Membership of Egyptian society of nuclear sciences and applications, Egypt.
· Editor and Reviewer in the Open Journal of Applied Chemistry and Biotechnology. Kindi Publication. 2013
Training courses and workshops
· 2009 Training on Drug design based computer, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
· 2003 Training on X-ray fluorescence and X-ray diffraction and its applications in nuclear sciences, Atomic Energy Authority, Egypt.
· 2002 Training on Protection and decontamination of radioactive waste, Atomic Energy Authority, Egypt.
· 2001Training on production and QC technology of gel Tc-99m generator and its use in nuclear medicine in nuclear power institute of china (2 months), China.
I am interested in reading in all specialties especially medical biochemistry and nuclear pharmacy.
Prof. Dr. Hassan M. E. Azzazy, PhD, SC(ASCP), DABCC, FACB
Professor of Chemistry. Leader, Novel Diagnostics & Therapeutics Research Group. School of sciences & engineering. The American University in Cairo
Email: [email protected]
Pr. Dr. Abdelfattah Attalla
professor of biochemistry, George Washington University, USA, ABC diagnostics, Egypt. Email: [email protected]
1. M. M. Abou-Mesalam. I. M. El-Naggar. M.S. Abdel-Hai. M. S. El-Shahawi, “Use of open cell resilient polyurethane foam loaded with crown ether for the preconcentration of uranium from aqueous solutions", Journal of nuclear chemistry, Vol. 258, N 3, 619 – 625 pages. Nov. (2004)
2. M. M. Abou-Mesalam. I. M. El-Naggar. M.S. Abdel-Hai. M. S. El-Shahawi, “ Determination of thermodynamic parameters for the adsorption of some radionuclides on titano-molybdate ion exchanger", Arab Journal of nuclear sciences and applications, (2003)
3. M. M. Abou-Mesalam. I. M. El-Naggar. M.S. Abdel-Hai. M. S. El-Shahawi, “Separation of some fission products from radioactive liquid waste solutions using titano-molybdate ion exchanger Arab Journal of nuclear sciences and applications, (2002)
4. M. M. Abou-Mesalam. I. M. El-Naggar. M.S. Abdel-Hai. M. S. El-Shahawi ,“Separation of some fission products from radioactive liquid waste solutions using titano-molybdate ion exchanger", Accepted in Arabic Conference for Academic Research on residues and the safe methods to recycling, 9-11March2003, Cairo – Egypt.
5. Abdou Osman. I. M. El-Naggar. M.S. Abdel-Hai. Mervat Abdelkader. Essam Zakaria ", Determination of collagen III as fibrotic marker in hepatitis C virus induced liver fibrosis (under publication)
6. Abdou Osman. I. M. El-Naggar. M.S. Abdel-Hai. Mervat Abdelkader. Essam Zakaria ", Radioimmunological studies in patients infected with hepatitis C virus (under publication)
2. Pharmaceutical biotechnology. (Under publication)
3. Radiopharmaceuticals. (Under publication)