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Yong Wang, Ph.D

Primary Affiliation
Northwestern University
United States of America


Paper Endorsements
Review Endorsements




Yong Wang

[email protected]

Research Scientist (2012-Present)





University of Missouri-Columbia



Biological Engineering

University of Missouri-Columbia



Biomedical Sciences

Nankai University



Animal Physiology and Biochemistry

Yangtze University



Applied Chemistry




A.        Areas of Expertise

      Single molecule detections; Patch-Clamp techniques; Single-Channel recordings; Electrophysiology, voltage-gated ion-channels; Genetic and epigenetic detections; Nanopore sensors; Nanopore sequencing; Biosensors; Nucleic acids (DNA, RNA) folding/unfolding; Interaction of nucleic acids with proteins; Nanoparticles; Peptide aggregations.


B.        Honors and Professional Memberships:


           1) 2012 Outstanding Graduate Student, University of Missouri-Columbia

           2) Student Talk at 56th Annual Biophysical Society Meeting, San Diego, California, Feb 25, 2012.

                   (Only two students were invited to give the talk at the Nanoscale Biophysics subgroup)

      Professional Memberships

           1) Society of Neuroscience (2007-2009)

           2) Biophysical Society (2009-present)


C.        Patents:

           1) Nanopore-Facilitated Single Molecule Detection of Nucleic Acids.

                INVENTOR(S): Li-Qun Gu; Yong Wang et al.

                (The patent was nationalized to the European    Patent Office under application 11807539.9 and to the Hong Kong, Australian, Canadian, and Japanese patent offices. CA2805247A1, EP2593568A2, EP2593568A4, US20130220809, WO2012009578 A3, WO2012009578A2).


           2) Base-pair specific inter-strand locks for genetic and epigenetic detection.

                INVENTOR(S): Li-Qun Gu; Yong Wang et al. Disclosure No: 14UMC007.


D: Book Chapter:

1.    Gu, L.Q, Wang Y. Nanopore Single-Molecule Detection of Circulating MicroRNAs. Circulating MicroRNAs: Methods and Protocols, (2013) Springer, 255-268. (Book Cover Image).


E.         Selected Publications:


1.     Wang Y. et al., Single Molecule Investigation of Ag+ Interactions with Single Cytosine-, Methylcytosine- and Hydroxymethylcytosine-Cytosine Mismatches in a Nanopore. Scientific Reports, 4, 5883 (2014). (Corresponding Author). (This publication has been reported by ScienceGate, NanoWerk, NanoDynamiX, Nanotechnology News Today and other media).


2.    Wang Y. et al., Probing Molecular Pathways for DNA Orientational Trapping, Unzipping and Translocation in Nanopore by Using an Tunable Overhang Sensor. Nanoscale, 6 (19), 11372-11379 (2014). (Corresponding Author). (This publication has been recommended on Pubadvanced, and reported by Before It’s News, Pubfacts and technology.popular-study.com).


3.    Wang, Y., Zheng, D., Tan, Q., Wang, M. and Gu, L.Q. Nanopore-based detection of circulating microRNAs in lung cancer patients. Nature Nanotechnology 6, 668-674 (2011). (This publication was highlighted by Nature Nanotechnology website. This work was reported by “Science Daily”, “Chemistry News”, “Nano Werk”, “Health Gspot”, “SentientCouchPotato”, and “Scientific American” and other media).


4.    Gu LQ, Ritzo B, Wang Y. When less is more in a nanopore. Nature Nanotechnology 7, 212-213 (2012).


5.    Zhang X. Wang Y. et al., Programming Nanopore Ion Flow for Encoded Multiplex MicroRNA Detection. Acs Nano, 8 (4), 3444-3450 (2014).


6.    Kang I. Wang Y. et al., Designing DNA interstrand lock for locus-specific methylation detection in a nanopore. Scientific Reports, 3, 2381, DOI: 10.1038/srep02381 (2013).


7.    K Tian, Z He, Wang Y.. et al., Designing a Polycationic Probe for Simultaneous Enrichment and Detection of MicroRNAs in a Nanopore. Acs Nano, 7 (5), 3962-3969 (2013).


8.    Zheng D, Haddadin S, Wang Y, Gu LQ, Perry MC, Freter CE, Wang MX. Plasma microRNAs as novel biomarkers for early detection of lung cancer. International Journal of Clinical and Experimental Pathology 4(6):575-86. (2011).


9.    Wang Y, Kuehl-Kovarik MC. Estradiol directly attenuates sodium currents and depolarizing afterpotentials in isolated gonadotropin-releasing hormone neurons. Brain Research 1436:81-91 (2012).


10.  Wang Y, Kuehl-Kovarik MC. Flufenamic acid modulates multiple currents in gonadotropin-releasing hormone neurons. Brain Research 1353:94-105 (2010).


11.  Wang Y, Garro M, Kuehl-Kovarik MC. Estradiol attenuates multiple tetrodotoxin-sensitive sodium currents in isolated gonadotropin-releasing hormone neurons. Brain Research 1345:137-45 (2010).


12.  Wang Y, Garro M, Dantzler HA, Taylor JA, Kline DD, Kuehl-Kovarik MC. Age affects spontaneous activity and depolarizing afterpotentials in isolated gonadotropin-releasing hormone neurons. Endocrinology149(10):4938-47 (2008).


1.    Wang Y. et al., Effects of Cyhalothrin on the Transient Outward Potassium Current in Central Neurons of Helicoverpa armigera. Insect Science, 2006,13, 13-17 (In English).


2.    Wang Y. et al., Inhibition Effects of Cyhalothrin on Delayed Rectifier Potassium Current in Central Neurons of Helicoverpa armigera. Acta Entomologica Sinica, 2006, 49(2), 235-240 (In English).


3.    Wang Y. et al., Recognize Chemical Pesticide and Biopesticide Reasonable, Pesticide Science and Administration, 2006, 27(2): 45-53.


4.    Zhao Q, Wang Y. et al., Modulations by pertussis toxin of the L-type Ca2+ channels in the central neurons of the resistant and susceptible cotton bollworm, Acta Scientiarum Naturalium Universitatis NanKaiensis, 2006, 39(1): 100-106.


5.    He B, Liu D, Wang Y. et al., Comparison of electrophysiological properties of sodium channels in central neurons cultured from sensitive and in insecticide-resistance cotton bollworm larvae. Acta Scientiarum Naturalium Universitatis NanKaiensis, 2004, 37(4): 111-114.


F: Presentations:

2007: Abstract, poster presentation at San Diego, Society for Neuroscience Annual meeting 2007;

         NN27 831 .13 Flufenamic acid increases currents underlying the depolarizing afterpotential in GnRH neurons trom young and aged animals. Wang Y, Garro M, Kuehl-Kovarik M.


2008: Abstract, poster presentation at Washington, Society for Neuroscience Annual meeting 2008;

         QQ3 81.5. Sodium inftux undertying the action potential and depolarizing afterpotential in isolated gonadotropin releasing hormone neurons. Wang Y, Garro M, Kuehl-Kovarik M.


2009: Abstract, poster presentation at Chicago, Society for Neuroscience Annual meeting 2009;

         DD50 186.17 Estrogen directly modulates sodiumcurrents in GnRH neurons in a time-of-day specific manner. Wang Y, Garro M, Kuehl-Kovarik M.


2010: Abstract, poster presentation at San Francisco, 54th Biophysical Society Annual meeting 2010; 

         3108-Pos B837 A novel single molecule signature for discriminating DNA unzipping in the nanopore. Wang Y, Tan QL, Gu LQ.


2011: Abstracts, posters (two) presentation at Maryland, 55th Biophysical Society Annual meeting 2011; 

           1) 927-Pos B727 A nanopore sensor for single molecule detection of circulating MicroRNAs in lung cancer patients. Wang Y, Zheng DL. Tan QL, Wang MX, Gu LQ.

           2) 918-Pos B718 Singel-molecule signature for characterization and regulation of nucleic acids unzipping in a nanopore. Wang Y, Gu LQ.


2012: Abstracts, posters (two) presentation at San Diego, 56th Biophysical Society Annual meeting 2012.

           1) Salt Gradient Enhances Small Molecules Capture in a Biological Nanopore. Wang Y, Kang Insoon, Tian K, Ritzo BA and Gu LQ.

           2) Oligomer Duplex Tearing and Shearing Mechanisms in the Nanopore. Wang Y, Gu LQ.


2013: Abstracts, posters presentation at Philadelphia, 57th Biophysical Society Annual meeting 2013.

          Enhancing Biopolymer Trapping by Double Electrical Filed and Osmotic Flow in a Biological Nanopore. Wang Y, Gu LQ.


2008: Research and Creative Activities Forum (RCAF), presentation;


2008: Central Missouri Chapter of the Society for Neuroscience: poster;


2008: Phi-Zeta Research Day, one poster and one presentation;


2010: Life Sciences Week, poster;


2011: Translational Neuroscience Symposium, poster;



G: Teaching and mentoring experience:


Nicholas Sun (Rock Bridge High School), whom I was teaching and mentoring during the summer 2010 and 2011 for the national “Siemens competition”, Nicholas is one of the Regional winners, and only three candidates were chosen from Missouri State. 


During these six month summer time, I taught Nicholas about the single channel recording techniques and the software first, also about the biological scientific area we were going to touch. After some training, Nicholas designed a project independently. He went through some experimental difficulties and problems and we had wonderful discussions to solve all these problems. He is a smart and diligent student and he can handle the experiments well pretty soon. Finally, we summarized all the results we have till this summer, and discussed about the conclusions we have reached. It is not surprising that Nicholas’ work was recognized by the “Siemens Competition” committee, and he will attend the following competitions which could lead him to be a winner of the “national finalists”.


The Siemens Competition in Math, Science & Technology recognizes remarkable talent early on, fostering individual growth for high school students who are willing to challenge themselves through science research. Through this competition, students have an opportunity to achieve national recognition for science research projects that they complete in high school.


H: Technical training and Research interests:


      Technical training: nerve cell culture (Central neurons of Helicoverpa Armigera; Rat hippocampal pyramidal neurons; Mouse Gonadotropin releasing hormone neruons); Electrophysiology; single-channel recording; Patch clamp techniques and other basic chemical and biological techniques.

      Research interests: Single molecular detection, nanopore biosensors, patch clamp electrophysiology, biophysics, peptide-nucleic acid interactions and ion channels gating.





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        The International Journal of Developments in Nanotechnology is a peer-reviewed, open access journal that publishes original research papers, review articles, and essays within nanotechnology. The aim of the IJDN is to promote innovative basic science and material applications of nanoscopic engineering, from DNA to silicon, atomic to molecular manipulations. Speculative and theoretical articles are also open to consideration.